Dichloromethane → 5-chloro-N-[2-[[3-(5-chloro-1-methyl-2-oxo-3-pyridinyl)-2-ethylphenyl]sulfonylamino]-3-(3-methylmorpholin-4-yl)-3-oxopropyl]thiophene-2-carboxamide
Reaction equation
[CH2:22]([c:23]1[c:24]([N:25]2[CH2:26][CH2:27][O:28][CH2:29][C:30]2=[O:31])[cH:32][cH:33][cH:34][c:35]1[S:36]([NH:37][CH:38]([C:39]([N:40]1[CH2:41][CH2:42][O:43][CH:44]([CH3:45])[CH2:46]1)=[O:47])[CH2:48][NH:49][C:50]([c:51]1[s:52][c:53]([Cl:54])[cH:55][cH:56]1)=[O:57])(=[O:58])=[O:59])[CH3:60].[CH2:94]1[O:95][CH2:96][CH2:97][O:98][CH2:99]1.[CH:61]([N:62]([CH2:63][CH3:64])[CH:65]([CH3:66])[CH3:67])([CH3:68])[CH3:69].[Cl:100][CH2:101][Cl:102].[Cl:70][c:71]1[cH:72][c:73](-[c:79]2[c:80]([CH2:89][CH3:90])[c:81]([S:85](=[O:86])(=[O:87])[Cl:88])[cH:82][cH:83][cH:84]2)[c:74](=[O:78])[n:75]([CH3:77])[cH:76]1.[Cl:91][CH2:92][Cl:93].[NH2:1][CH:2]([CH2:3][NH:4][C:5](=[O:6])[c:7]1[s:8][c:9]([Cl:12])[cH:10][cH:11]1)[C:13](=[O:14])[N:15]1[CH:16]([CH3:21])[CH2:17][O:18][CH2:19][CH2:20]1>>[NH:1]([CH:2]([CH2:3][NH:4][C:5](=[O:6])[c:7]1[s:8][c:9]([Cl:12])[cH:10][cH:11]1)[C:13](=[O:14])[N:15]1[CH:16]([CH3:21])[CH2:17][O:18][CH2:19][CH2:20]1)[S:85]([c:81]1[c:80]([CH2:89][CH3:90])[c:79](-[c:73]2[cH:72][c:71]([Cl:70])[cH:76][n:75]([CH3:77])[c:74]2=[O:78])[cH:84][cH:83][cH:82]1)(=[O:86])=[O:87]Participants
7
Reactant 6
HCID 6344Dichloromethane2×
HCID 312751,4-Dioxane
HCID 81531Diisopropylethylamine
HCID 867617693-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride
HCID 178431603HCID 178431603, compound
HCID 1784369995-chloro-N-[2-[[2-ethyl-3-(3-oxomorpholin-4-yl)phenyl]sulfonylamino]-3-(2-methylmorpholin-4-yl)-3-oxopropyl]thiophene-2-carboxamideProduct 1
Sources & evidence
- ORD record
- ord-ac47a244b8714a74a1aa58d0900232fb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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