Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxylamine → (1S,2S,5R)-N-hydroxy-2-[(4-phenylpiperazin-1-yl)carbonyl]-5-(pyridin-3-ylmethoxy)cyclohexanecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | methyl(1S,2S,5R)-2-[(4-phenylpiperazin-1-yl)carbonyl]-5-(pyridin-3-ylmethoxy)cyclohexanecarboxylate | HCID 67305585 | — |
| 생성물 | (1S,2S,5R)-N-hydroxy-2-[(4-phenylpiperazin-1-yl)carbonyl]-5-(pyridin-3-ylmethoxy)cyclohexanecarboxamide | HCID 86598268 | — |
반응 단계
1.5 M of hydroxyamine solution (0.7 ml) was added to a solution of methyl(1S,2S,5R)-2-[(4-phenylpiperazin-1-yl)carbonyl]-5-(pyridin-3-ylmethoxy)cyclohexanecarboxylate (0.075 mmol, 0.000075 mol) made above in methanol (0.5 mL, 0.01 mol). It was stirred at rt for 2 hrs then purified by Prep-HPLC. LCMS: (M+H)+=439.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07491724B2 |
| 출처 데이터셋 | uspto-grants-2009_02 |
| ORD ID | ord-d4497f94ad3a41f9b56a143484639c76 |
| 출처 메모 | uspto-grants-2009_02 |