HRID1726706

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID787

Hydroxylamine

H3NO

结构：COC(=O)[C@H]1C[C@H](Oc2cncc(Cl)c2)CN(C(=O)OC(C)(C)C)[C@@H]1C(=O)N1CC=C(c2cc(C)c(C#N)c(C)c2)CC1

HCID86621495

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H]1C[C@@H](O)CN(C(=O)OC(C)(C)C)[C@@H]1C(=O)N1CC=C(c2cc(C)c(C#N)c(C)c2)CC1

HCID86621496

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Part 7. 1-tert-butyl 3-methyl(2S,3S,5S)-5-[(5-chloropyridin-3-yl)oxy]-2-[4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1 (2H)-yl]carbonylpiperidine-1,3-dicarboxylate was treated with hydroxylamine solution in methanol, using procedures analogous to those for example 152, to provide the titled product. ESI MS: (M+H) 510.1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e756872c7c0f4d019d42bae3d056138b
来源数据集: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07491724B2
来源说明: uspto-grants-2009_02

反应 SMILES

ClC1C=C([O:8][C@@H:9]2[CH2:14][N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C@H:12]([C:22]([N:24]3[CH2:29][CH:28]=[C:27]([C:30]4[CH:35]=[C:34]([CH3:36])[C:33]([C:37]#[N:38])=[C:32]([CH3:39])[CH:31]=4)[CH2:26][CH2:25]3)=[O:23])[C@@H:11]([C:40]([O:42][CH3:43])=[O:41])[CH2:10]2)C=NC=1.NO>CO>[C:37]([C:33]1[C:34]([CH3:36])=[CH:35][C:30]([C:27]2[CH2:28][CH2:29][N:24]([C:22]([C@@H:12]3[C@@H:11]([C:40]([O:42][CH3:43])=[O:41])[CH2:10][C@@H:9]([OH:8])[CH2:14][N:13]3[C:15]([O:17][C:18]([CH3:20])([CH3:19])[CH3:21])=[O:16])=[O:23])[CH2:25][CH:26]=2)=[CH:31][C:32]=1[CH3:39])#[N:38]