Tetrahydrofuran → methyl 2-[(2'-oxospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-1'(2'H)-yl)methyl]-1,3-oxazole-4-carboxylate

HRID 172692Notes

Reaction equation

HRID 172692 reaction equation
[C:33](=[O:34])([O-:35])[O-:36].[Cl:22][CH2:23][c:24]1[o:25][cH:26][c:27]([C:29](=[O:30])[O:31][CH3:32])[n:28]1.[Cs+:37].[Cs+:38].[NH:1]1[C:2](=[O:21])[C:3]2([CH2:4][O:5][c:6]3[c:7]2[cH:8][c:9]2[c:10]([cH:14]3)[O:11][CH2:12][O:13]2)[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21.[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1>>[N:1]1([CH2:23][c:24]2[o:25][cH:26][c:27]([C:29](=[O:30])[O:31][CH3:32])[n:28]2)[C:2](=[O:21])[C:3]2([CH2:4][O:5][c:6]3[c:7]2[cH:8][c:9]2[c:10]([cH:14]3)[O:11][CH2:12][O:13]2)[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 2763199Methyl 2-(chloromethyl)oxazole-4-carboxylateHCID 53375495spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Product 1

HCID 68599804methyl 2-[(2'-oxospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-1'(2'H)-yl)methyl]-1,3-oxazole-4-carboxylate

Sources & evidence

ORD record
ord-a1dc0c3b1e054ed2be642cd417950fe2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…