Hydrazine hydrate (1:1) → HCID 178516754, compound

HRID 1726922Notes

Reaction equation

HRID 1726922 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8](C)[CH2:9][C:10](O)=[O:11])=S)=[CH:4][CH:3]=1.O.[NH2:17][NH2:18]>CO>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]2[NH:8][CH2:9][C:10](=[O:11])[NH:18][N:17]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86595218HCID 86595218, compound

Product 1

HCID 178516754HCID 178516754, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Chlorothiobenzoyl methyl glycine (4.87 g, 20 mmol), 2.2 g of hydrazine hydrate (44 mmol) and 20 mL of methanol were combined and stirred at room temperature overnight, then heated to reflux. The reaction mixture was cooled and filtered. The solids were washed, then dried, giving 3-(4-chlorophenyl)-4,5-dihydro-1,2,4-triazin-6-one.

Workup

  1. temperatureheated to reflux
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered
  4. washThe solids were washed
  5. customdried

Sources & evidence

ORD record
ord-9331fd88555d4550b7803d6891e153ad
Source dataset
uspto-grants-2009_02
Patent number
US07494996B2

Reaction notes

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