Ethyl Acetate → HCID 178494027, compound

HRID 1726930Notes

Reaction equation

HRID 1726930 reaction equation
[F:1][C:2]([F:20])([F:19])[CH2:3][N:4]1[C:9](=[O:10])[CH:8]=[N:7][C:6]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[C:13]([Cl:18])[CH:12]=2)=[N:5]1.[C:21](OCC)(=[O:23])C>CO>[F:20][C:2]([F:1])([F:19])[CH2:3][N:4]1[C:9](=[O:10])[CH:8]([O:23][CH3:21])[NH:7][C:6]([C:11]2[CH:12]=[C:13]([Cl:18])[CH:14]=[C:15]([Cl:17])[CH:16]=2)=[N:5]1

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 68957104HCID 68957104, compound

Product 1

HCID 178494027HCID 178494027, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1-(2,2,2-trifluoroethyl)-3-(3,5-dichlorophenyl)-1,2,4-triazin-6-one (70 mg, 0.21 mmol) dissolved in 3 mL of a 1:1 mixture of ethyl acetate and methanol was added a small scoopula of neutral alumina. After stirring for 20 minutes, the mixture was filtered through a small plug of glass wool and concentrated. The product (80 mg) was afforded in 96% purity and 100% yield.

Workup

  1. additionwas added a small scoopula of neutral alumina
  2. filtrationthe mixture was filtered through a small plug of glass wool
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-94fcffc34c754139ba89528ff4435c8a
Source dataset
uspto-grants-2009_02
Patent number
US07494996B2

Reaction notes

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