Potassium Carbonate → HCID 86087963, compound

HRID 1726954Notes

Reaction equation

HRID 1726954 reaction equation
[CH2:1](Br)[C:2]#[C:3][CH3:4].[CH2:6]([O:8][C:9]([CH2:11][NH:12][C:13](=[N:21][C:22]#[N:23])[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10])[CH3:7].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:6]([O:8][C:9]([CH2:11][N:12]([CH2:1][C:2]#[C:3][CH3:4])[C:13](=[N:21][C:22]#[N:23])[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10])[CH3:7]

Participants

5

Reactant 3

HCID 11430Potassium Carbonate2×HCID 27568621-Bromo-2-butyne2×HCID 178472744HCID 178472744, compound

Product 1

HCID 86087963HCID 86087963, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

11 ml of but-2-ynylbromide are added to a mixture of 30.2 g 1-ethoxycarbonylmethyl-3-cyano-2-phenyl-isourea and 20.0 g potassium carbonate in 200 ml acetone. After 1 d (day) stirring at ambient temperature a further 6.5 g potassium carbonate and 3.5 ml of but-2-ynylbromide are added. After another 20 h at ambient temperature the solvent is removed and ethyl acetate is added. The organic phase is washed with water, dried over sodium sulphate and evaporated to dryness.

Workup

  1. additionare added
  2. customAfter another 20 h at ambient temperature the solvent is removed
  3. additionethyl acetate is added
  4. washThe organic phase is washed with water
  5. dry with materialdried over sodium sulphate
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-d394de6702a34152aaa38e9a26058c7e
Source dataset
uspto-grants-2009_02
Patent number
US07495003B2

Reaction notes

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