Hydrochloric Acid → HCID 11649250, compound

Participants

Reaction Steps

2 ml of 1 M sodium hydroxide solution are added to a solution of 150 mg of (R)-1-(4-methyl-quinazolin-2-ylmethyl)-3-(methoxycarbonylmethyl )-7-(but-2-ynyl)-8-(3-amino-piperidin-1-yl)-xanthine in 6 ml of tetrahydrofuran/water/methanol (1:1:1). The solution is stirred for 1 h at ambient temperature and then neutralised with 1 M hydrochloric acid. The solution is evaporated to dryness and purified by HPLC (YMC-C18) with water/acetonitrile (70:30).

Provenance & Evidence