Hydrochloric Acid → HCID 11649250, compound

HRID 1726960Notes

Reaction equation

HRID 1726960 reaction equation
[OH-].[Na+].[CH3:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([CH2:14][N:15]2[C:24](=[O:25])[C:23]3[N:22]([CH2:26][C:27]#[C:28][CH3:29])[C:21]([N:30]4[CH2:35][CH2:34][CH2:33][C@@H:32]([NH2:36])[CH2:31]4)=[N:20][C:19]=3[N:18]([CH2:37][C:38]([O:40]C)=[O:39])[C:16]2=[O:17])[N:5]=1.Cl>O1CCCC1.O.CO>[CH3:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([CH2:14][N:15]2[C:24](=[O:25])[C:23]3[N:22]([CH2:26][C:27]#[C:28][CH3:29])[C:21]([N:30]4[CH2:35][CH2:34][CH2:33][C@@H:32]([NH2:36])[CH2:31]4)=[N:20][C:19]=3[N:18]([CH2:37][C:38]([OH:40])=[O:39])[C:16]2=[O:17])[N:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11606204HCID 11606204, compound

Product 1

HCID 11649250HCID 11649250, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

2 ml of 1 M sodium hydroxide solution are added to a solution of 150 mg of (R)-1-(4-methyl-quinazolin-2-ylmethyl)-3-(methoxycarbonylmethyl )-7-(but-2-ynyl)-8-(3-amino-piperidin-1-yl)-xanthine in 6 ml of tetrahydrofuran/water/methanol (1:1:1). The solution is stirred for 1 h at ambient temperature and then neutralised with 1 M hydrochloric acid. The solution is evaporated to dryness and purified by HPLC (YMC-C18) with water/acetonitrile (70:30).

Workup

  1. customThe solution is evaporated to dryness
  2. custompurified by HPLC (YMC-C18) with water/acetonitrile (70:30)

Sources & evidence

ORD record
ord-210f3b66a1e14629b694d8eff3c51826
Source dataset
uspto-grants-2009_02
Patent number
US07495003B2

Reaction notes

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