反应详情

0.470 g (1.77 mmol) of the above prepared 2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde was dissolved in 9 ml of abs. THF and treated at −10° C. with 0.89 ml of 3M methyl magnesium chloride solution (in THF). After 15 Min., the reaction mixture was carefully poured onto crashed ice/NH4Cl, extracted twice with AcOEt, washed with water and brine, dried over sodium sulfate, and evaporated to dryness to leave 0.508 g of the title product, pure according to NMR.

1. dissolutionwas dissolved in 9 ml of abs
2. addition, the reaction mixture was carefully poured
3. extractionextracted twice with AcOEt
4. washwashed with water and brine
5. dry with materialdried over sodium sulfate
6. customevaporated to dryness