反应详情

4.00 g (15.1 mmol) of (4-benzyloxy-naphthalen-2-yl)-methanol [PCT Int. Appl. (1997), WO 97/09311A1] was dissolved in 160 ml of EtOAc; then, 54.1 g of manganese dioxide was added in small portions and the reaction mixture was stirred for 30 Min. at ambient temperature. The dark suspension was filtered with the aid of dicalite; then, the solvent was evaporated. Flash chromatography (SiO2, hexane/EtOAc=4:1) gave 3.20 g of the title compound as colorless oil.

1. customat ambient temperature
2. filtrationThe dark suspension was filtered with the aid of dicalite
3. customthen, the solvent was evaporated