3-Chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine → HCID 69036918, compound

HRID 1727004Notes

Reaction equation

HRID 1727004 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[C:5]([CH3:20])([O:7][C:8]1[C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[C:11]([NH:18][CH3:19])=[CH:10][CH:9]=1)[CH3:6])[CH3:2].Cl[CH2:23][C:24]1[C:25]([CH3:40])=[N:26][C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=2)=[CH:28][CH:29]=1>>[CH2:1]([O:3][C:4](=[O:21])[C:5]([CH3:20])([O:7][C:8]1[C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[C:11]([N:18]([CH3:19])[CH2:23][C:24]2[C:25]([CH3:40])=[N:26][C:27]([C:30]3[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=3)=[CH:28][CH:29]=2)=[CH:10][CH:9]=1)[CH3:6])[CH3:2]

Participants

3

Reactant 2

HCID 219357513-Chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridineHCID 69037484HCID 69037484, compound

Product 1

HCID 69036918HCID 69036918, compound

Procedure

In analogy to the procedures described in example 5C] and 5D], 2-methyl-2-(4-methylamino-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-propionic acid ethyl ester was reacted with 3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example 4G]) to give 2-methyl-2-(4-{methyl-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-amino}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-propionic acid ethyl ester, which was subsequently saponified to yield the title compound as colorless solid.

Sources & evidence

ORD record
ord-e9334feb4ff8414ca39e7c594e791fe2
Source dataset
uspto-grants-2009_02
Patent number
US07495001B2

Reaction notes

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