HRID1727004

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21935751

未命名化合物

HCID69037484

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(C)(C)Oc1ccc(N(C)Cc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)c2c1CCCC2

HCID69036918

未命名化合物

PROCEDURE

实验过程

In analogy to the procedures described in example 5C] and 5D], 2-methyl-2-(4-methylamino-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-propionic acid ethyl ester was reacted with 3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example 4G]) to give 2-methyl-2-(4-{methyl-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-amino}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-propionic acid ethyl ester, which was subsequently saponified to yield the title compound as colorless solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e9334feb4ff8414ca39e7c594e791fe2
来源数据集: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07495001B2
来源说明: uspto-grants-2009_02

反应 SMILES

[CH2:1]([O:3][C:4](=[O:21])[C:5]([CH3:20])([O:7][C:8]1[C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[C:11]([NH:18][CH3:19])=[CH:10][CH:9]=1)[CH3:6])[CH3:2].Cl[CH2:23][C:24]1[C:25]([CH3:40])=[N:26][C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=2)=[CH:28][CH:29]=1>>[CH2:1]([O:3][C:4](=[O:21])[C:5]([CH3:20])([O:7][C:8]1[C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[C:11]([N:18]([CH3:19])[CH2:23][C:24]2[C:25]([CH3:40])=[N:26][C:27]([C:30]3[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=3)=[CH:28][CH:29]=2)=[CH:10][CH:9]=1)[CH3:6])[CH3:2]