4-Bromo-3-fluorobenzotrifluoride → 1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine

HRID 1727065Notes

Reaction equation

HRID 1727065 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.BrC1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=1[F:25]>>[F:25][C:16]1[CH:17]=[C:18]([C:21]([F:24])([F:23])[F:22])[CH:19]=[CH:20][C:6]=1[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 1424144-Bromo-3-fluorobenzotrifluorideHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 468374951-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine

Procedure

The compound 1-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine is synthesized according to the procedure outlined in Example 26 steps 1 and 2 using t-butyl-1-piperazine-carboxylate and 1-bromo-2-fluoro-4-trifluoromethyl-benzene.

Sources & evidence

ORD record
ord-00daf392c2fa4aab8b16b27a2be078dc
Source dataset
uspto-grants-2009_02
Patent number
US07494999B2

Reaction notes

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