反应详情

4-(2-fluoro-phenoxy)-2-nitrotoluene (15.17 g, 0,061 mol) and Pd/C (1.67 g) in ethanol (150 mL) were stirred under hydrogen atmosphere for 48 h, then the mixture was filtered through celite and the filtrate was concentrated under vacuum and purified by flash chromatography eluting with Hex:EtOAc 9:1 to afford 10.9 g of 5-(2-fluoro-phenoxy)-2-methyl-phenylamine: MS: 218 (M+H).

1. filtrationthe mixture was filtered through celite
2. concentrationthe filtrate was concentrated under vacuum
3. custompurified by flash chromatography
4. washeluting with Hex