HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Fluoro-phenoxy)-2-nitrotoluene → 5-(2-Fluoro-phenoxy)-2-methyl-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Fluoro-phenoxy)-2-nitrotoluene | HCID 57566688 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(2-Fluoro-phenoxy)-2-methyl-phenylamine | HCID 57566690 | 0.1% |
Reaction Steps
4-(2-fluoro-phenoxy)-2-nitrotoluene (15.17 g, 0,061 mol) and Pd/C (1.67 g) in ethanol (150 mL) were stirred under hydrogen atmosphere for 48 h, then the mixture was filtered through celite and the filtrate was concentrated under vacuum and purified by flash chromatography eluting with Hex:EtOAc 9:1 to afford 10.9 g of 5-(2-fluoro-phenoxy)-2-methyl-phenylamine: MS: 218 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07495015B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-0b7f32ac9a5746db9362f56e36d918e8 |
| Source note | uspto-grants-2009_02 |