反应详情

温度

50 °C

Nitro-compound 16 (4 g) was partially dissolved in 75 mL EtOAc/75 mL EtOH/75 mL dioxane, and a suspension of Raney Ni was added. The mixture was flushed with H2 three times. The mixture was stirred under H2 at 50° C. overnight, then filtered through celite. Concentration and chromatography of the residue on silica gel gave 2.2 g of the desired product. Yield: 88%.

1. additionwas added
2. customThe mixture was flushed with H2 three times
3. filtrationfiltered through celite
4. concentrationConcentration and chromatography of the residue on silica gel