反应详情

温度

125 °C

2-Chloro-3-methylquinoxaline (1.0 g, 5.6 mmol) and N-benzylpiperazine (2.9 ml, 16.8 mmol) were mixed and heated to 125° C. for 18 h. Saturated aqueous sodium hydrogen carbonate was added and the product was extracted with chloroform. The combined organic extracts were dried (Na2SO4) and concentrated in vacuo to give a dark red oil. The crude product was purified by flash chromatography using silica gel eluting with methanol:dichloromethane (15:85) to give the pure product as a red oil which solidified upon standing (1.63 g, 94%).

1. extractionthe product was extracted with chloroform
2. dry with materialThe combined organic extracts were dried (Na2SO4)
3. concentrationconcentrated in vacuo
4. customto give a dark red oil
5. customThe crude product was purified by flash chromatography