Chlorosuccinimide → HCID 12071591, compound

HRID 1727242Notes

Reaction equation

HRID 1727242 reaction equation
[NH:1]([C:8]1[C:18](=[O:19])[C:12]2[N:13]=[C:14]([CH2:16][CH3:17])[O:15][C:11]=2[C:10](=[O:20])[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:21]N1C(=O)CCC1=O>C(O)(=O)C>[NH:1]([C:8]1[C:18](=[O:19])[C:12]2[N:13]=[C:14]([CH2:16][CH3:17])[O:15][C:11]=2[C:10](=[O:20])[C:9]=1[Cl:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 12071587AGN-PC-0NHP1N

Product 1

HCID 12071591HCID 12071591, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 5-anilino-2-ethyl-1,3-benzoxazole-4,7-dione (1 eq.) in acetic acid is treated with N-chlorosuccinimide (1.1 eq.) at ambient temperature. The reaction medium is maintained under stirring for 2 hours before being concentrated, followed by taking up in ethanol and concentrating again. The residue is purified by medium pressure chromatography on silica in order to produce a violet-coloured powder.

Workup

  1. temperatureThe reaction medium is maintained
  2. concentrationbefore being concentrated
  3. concentrationconcentrating again
  4. customThe residue is purified by medium pressure chromatography on silica in order
  5. customto produce a violet-coloured powder

Sources & evidence

ORD record
ord-b0ce1351a7af48bdaa338f10d862a8bf
Source dataset
uspto-grants-2009_02
Patent number
US07495021B2

Reaction notes

Loading…