Benzeneacetic acid, alpha-bromo-, methyl ester → HCID 21985926, compound

HRID 1727284Notes

Reaction equation

HRID 1727284 reaction equation
[Cl:1][C:2]1[C:3]([OH:20])=[C:4]([CH2:17][CH2:18][CH3:19])[C:5]2[O:9][N:8]=[C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:6]=2[CH:16]=1.Br[CH:22]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:23]([O:25][CH3:26])=[O:24]>>[Cl:1][C:2]1[C:3]([O:20][CH:22]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:23]([O:25][CH3:26])=[O:24])=[C:4]([CH2:17][CH2:18][CH3:19])[C:5]2[O:9][N:8]=[C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:6]=2[CH:16]=1

Participants

3

Reactant 2

HCID 137806Benzeneacetic acid, alpha-bromo-, methyl esterHCID 135723523HCID 135723523, compound

Product 1

HCID 21985926HCID 21985926, compound

Procedure

The phenol of step 1 (0.25 g, 0.86 mmol) was coupled with commercially available methyl 2-bromo-2-phenylacetate (0.20 g, 0.86 mmol) as was described for example 9, step 5. The product was purified by chromatography on silica gel eluting with ethyl acetate:hexane (10:90).

Workup

  1. customThe product was purified by chromatography on silica gel eluting with ethyl acetate:hexane (10:90)

Sources & evidence

ORD record
ord-8cfecc54c15b4c01a73d6dcc68127bd9
Source dataset
uspto-grants-2009_02
Patent number
US07495020B2

Reaction notes

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