Thionyl Chloride → 3-Ethylbenzoyl chloride

HRID 1727342Notes

Reaction equation

HRID 1727342 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](O)=[O:7])[CH3:2].S(Cl)([Cl:14])=O>CN(C)C=O>[CH2:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([Cl:14])=[O:7])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 96207Benzoic acid, 3-ethyl-

Product 1

HCID 128093233-Ethylbenzoyl chloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

3-ethylbenzoic acid (9.40 g, 62.6 mmol) was added slowly to thionyl chloride (45 mL), and N,N-dimethylformamide (3 drops) was added dropwise. The resulting reaction mixture was heated under reflux for 2 hours under the same condition. The reaction mixture was concentrated, and used in the subsequent reaction without further purification.

Workup

  1. additionwas added dropwise
  2. customThe resulting reaction mixture
  3. temperaturewas heated
  4. temperatureunder reflux for 2 hours under the same condition
  5. concentrationThe reaction mixture was concentrated
  6. customused in the subsequent reaction without further purification

Sources & evidence

ORD record
ord-f0eab25cdaa44f5e87e4a7caf32f7d36
Source dataset
uspto-grants-2009_02
Patent number
US07495018B2

Reaction notes

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