Hydrochloric Acid → HCID 17862937, compound

HRID 1727357Notes

Reaction equation

HRID 1727357 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[S:12][C:11]([CH2:13][C:14]([O:16]CC)=[O:15])=[N:10][C:9]=2[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[CH:20]=2)[CH:5]=[CH:4][N:3]=1.[OH-].[Na+].Cl>C(O)C>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[S:12][C:11]([CH2:13][C:14]([OH:16])=[O:15])=[N:10][C:9]=2[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[CH:20]=2)[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11717324ETHYL [5-(2-AMINO-4-PYRIDYL)-4-(3-METHYLPHENYL)-1,3-THIAZOL-2-YL]ACETATE

Product 1

HCID 17862937HCID 17862937, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]acetate (7.00 g, 19.8 mmol) in ethanol (40 mL) was added a 1N aqueous sodium hydroxide solution (40 mL), and the mixture was stirred for 2 hours at the room temperature under the same condition, The reaction mixture was neutralized with 2N hydrochloric acid (20 mL), then, the produced solid was collected by filtration. The crude product was washed with water, and dried to obtain a title compound (6.10 g, yield: 95%).

Workup

  1. filtrationthe produced solid was collected by filtration
  2. washThe crude product was washed with water
  3. customdried

Sources & evidence

ORD record
ord-46dfd121cffc456f96112f004738631d
Source dataset
uspto-grants-2009_02
Patent number
US07495018B2

Reaction notes

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