Acetic Acid → Methyl 2-[2-[1-[1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]acetate

HRID 172763Notes

Reaction equation

HRID 172763 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[N:5]1[CH2:6][CH:7]([C:18](=[O:19])[N:20]2[CH2:21][CH2:22][C:23]([c:26]3[c:27]([CH2:33][C:34](=[O:35])[O:36][CH3:37])[cH:28][c:29]([Cl:32])[cH:30][cH:31]3)=[CH:24][CH2:25]2)[CH:8]([c:10]2[c:11]([F:17])[cH:12][c:13]([F:16])[cH:14][cH:15]2)[CH2:9]1.[CH3:38][C:39](=[O:40])[OH:41].[Pt:42](=[O:43])=[O:44]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[N:5]1[CH2:6][CH:7]([C:18](=[O:19])[N:20]2[CH2:21][CH2:22][CH:23]([c:26]3[c:27]([CH2:33][C:34](=[O:35])[O:36][CH3:37])[cH:28][c:29]([Cl:32])[cH:30][cH:31]3)[CH2:24][CH2:25]2)[CH:8]([c:10]2[c:11]([F:17])[cH:12][c:13]([F:16])[cH:14][cH:15]2)[CH2:9]1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 345198Adams' catalystHCID 23525686HCID 23525686, compound

Product 1

HCID 23525688Methyl 2-[2-[1-[1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]acetate

Sources & evidence

ORD record
ord-e24424cf5a8149f1b0f1a1ae6aeae8f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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