Ammonium Hydroxide → 2-Tert-butyl-5-nitrobenzene-1-sulfonamide

HRID 1727645Notes

Reaction equation

HRID 1727645 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[S:14](Cl)(=[O:16])=[O:15])([CH3:4])([CH3:3])[CH3:2].[NH4+:18].[OH-]>CCOCC.O>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[S:14]([NH2:18])(=[O:16])=[O:15])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 574702642-Tert-butyl-5-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 574702652-Tert-butyl-5-nitrobenzene-1-sulfonamideYield 34%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 2-tert-butyl-5-nitrobenzene-1-sulfonyl chloride (100 mg, 0.36 mmol) in ether (2 mL) was added aqueous NH4OH (128 μL, 3.6 mmol) at 0° C. The mixture was stirred at room temperature overnight, diluted with water and extracted with ether. The combined ether extracts were washed with brine and dried over Na2SO4. After removal of solvent, the residue was purified by column chromatography (0-50% EtOAc-Hexane) to give 2-tert-butyl-5-nitrobenzene-1-sulfonamide (31.6 mg, 34%).

Workup

  1. extractionextracted with ether
  2. washThe combined ether extracts were washed with brine
  3. dry with materialdried over Na2SO4
  4. customAfter removal of solvent
  5. customthe residue was purified by column chromatography (0-50% EtOAc-Hexane)

Sources & evidence

ORD record
ord-1853ff7464274b3e85ef924ee57b2270
Source dataset
uspto-grants-2009_02
Patent number
US07495103B2

Reaction notes

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