Methanol → HCID 23022741, compound

HRID 1727873Notes

Reaction equation

HRID 1727873 reaction equation
[CH3:1][C:2]([CH3:39])([CH3:38])[CH2:3][CH2:4][NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[C:25]3[C:20](=[CH:21][C:22]([O:28][CH2:29][CH2:30][N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[C:23]([O:26][CH3:27])[CH:24]=3)[N:19]=[CH:18][CH:17]=2)=[CH:11][C:10]=1[F:37])=[O:7].CO.C(Cl)(Cl)[Cl:43]>Cl.CO>[ClH:43].[CH3:1][C:2]([CH3:39])([CH3:38])[CH2:3][CH2:4][NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[C:25]3[C:20](=[CH:21][C:22]([O:28][CH2:29][CH2:30][N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[C:23]([O:26][CH3:27])[CH:24]=3)[N:19]=[CH:18][CH:17]=2)=[CH:11][C:10]=1[F:37])=[O:7]

Participants

5

Reactant 3

HCID 887MethanolHCID 6212ChloroformHCID 23022742HCID 23022742, compound

Product 1

HCID 23022741HCID 23022741, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolCatalyst

Procedure

1-(3,3-Dimethyl-butyl)-3-{2-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-phenyl}-urea (42.7 mg) was dissolved in chloroform (1 ml) and methanol (1 ml) to prepare a solution. To the solution was added 10 drops of 10% hydrogen chloride-methanol with a Pasteur pipette. The mixture was concentrated by an evaporator, and the concentrate was dried by means of a vacuum pump to give a hydride compound (48.9 mg).

Workup

  1. concentrationThe mixture was concentrated by an evaporator
  2. customthe concentrate was dried by means of a vacuum pump

Sources & evidence

ORD record
ord-2a282fab870c476bb3826dca51d62e02
Source dataset
uspto-grants-2009_02
Patent number
US07495104B2

Reaction notes

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