Methanol → HCID 23022689, compound

HRID 1727875Notes

Reaction equation

HRID 1727875 reaction equation
CO.[CH3:3][C:4]([CH3:41])([CH3:40])[CH2:5][CH2:6][NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[C:27]3[C:22](=[CH:23][C:24]([O:30][CH2:31][CH2:32][N:33]4[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]4)=[C:25]([O:28][CH3:29])[CH:26]=3)[N:21]=[CH:20][CH:19]=2)=[CH:13][C:12]=1[F:39])=[O:9].[ClH:42].CO>C(Cl)(Cl)Cl>[ClH:42].[CH3:3][C:4]([CH3:41])([CH3:40])[CH2:5][CH2:6][NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[C:27]3[C:22](=[CH:23][C:24]([O:30][CH2:31][CH2:32][N:33]4[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]4)=[C:25]([O:28][CH3:29])[CH:26]=3)[N:21]=[CH:20][CH:19]=2)=[CH:13][C:12]=1[F:39])=[O:9]

Participants

5

Reactant 3

HCID 887MethanolHCID 9915207HCID 9915207, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 23022689HCID 23022689, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Methanol (20 ml) and chloroform (2 ml) were added to 1-(3,3-dimethyl-butyl)-3-{2-fluoro-4-[6-methoxy-7-(2-piperidin-1-yl-ethoxy)-quinolin-4-yloxy]-phenyl}-urea to prepare a solution. Hydrogen chloride-methanol was added to the solution, and the mixture was acidified and was concentrated. Diethyl ether was added to the residue, and mixture was filtrated to give the title compound (1.75 g, yield 91%).

Workup

  1. customto prepare a solution
  2. concentrationwas concentrated
  3. additionDiethyl ether was added to the residue, and mixture
  4. filtrationwas filtrated

Sources & evidence

ORD record
ord-6303cb9c7ebe41e28fbc70a6bd354d2a
Source dataset
uspto-grants-2009_02
Patent number
US07495104B2

Reaction notes

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