Methanol → 1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3,3-dimethyl-butyl)-urea hydrochloride

HRID 1727877Notes

Reaction equation

HRID 1727877 reaction equation
CO.[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][CH:9]=[C:8]2[O:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25]([NH:27][CH2:28][CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:26])=[CH:20][CH:19]=1.[ClH:34].CO>C(Cl)(Cl)Cl>[ClH:34].[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][CH:9]=[C:8]2[O:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25]([NH:27][CH2:28][CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:26])=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 21893726Hydrochloride methanolHCID 230226651-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3,3-dimethyl-butyl)-urea

Product 1

HCID 230227261-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3,3-dimethyl-butyl)-urea hydrochlorideYield 91%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Methanol (20 ml) and chloroform (2 ml) were added to 1-[4-(6,7-dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3,3-dimethyl-butyl)-urea to prepare a solution. The solution was acidified by the addition of hydrogen chloride-methanol, and the acidified solution was concentrated. Diethyl ether was added to the residue, and the mixture was filtrated to give the title compound (1.75 g, yield 91%).

Workup

  1. customto prepare a solution
  2. concentrationthe acidified solution was concentrated
  3. additionDiethyl ether was added to the residue
  4. filtrationthe mixture was filtrated

Sources & evidence

ORD record
ord-a298dd5e1c3a4498b2c7cc5059a4eb15
Source dataset
uspto-grants-2009_02
Patent number
US07495104B2

Reaction notes

Loading…