Hydrochloric Acid → HCID 9870622, compound

HRID 1727903Notes

Reaction equation

HRID 1727903 reaction equation
C(CC[O:5][C:6]([C:8]1[CH:13]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=2)[C:12]([C:21](=[O:38])[NH:22][CH2:23][CH2:24][CH:25]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:11]([CH3:39])[NH:10][C:9]=1[CH3:40])=[O:7])#N.[OH-].[Na+].Cl>CO>[Cl:20][C:16]1[CH:15]=[C:14]([CH:13]2[C:12]([C:21](=[O:38])[NH:22][CH2:23][CH2:24][CH:25]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)=[C:11]([CH3:39])[NH:10][C:9]([CH3:40])=[C:8]2[C:6]([OH:7])=[O:5])[CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18318269HCID 18318269, compound

Product 1

HCID 9870622HCID 9870622, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

275 mg (0.500 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-5-(3,3-diphenylpropylcarbamoyl)-1,4-dihydropyridine-3-carboxylic acid 2-cyanoethyl ester was dissolved in 10 ml of methanol. 1 ml of 1 N aqueous sodium hydroxide solution was added and stirred at room temperature for 7.5 hours. After adding 2 N hydrochloric acid, methanol was evaporated under reduced pressure. Water was added to the residue, and precipitates thus formed were taken by the filtration, then washed with water and hexane/ethyl acetate (3/1) and dried under reduced pressure to obtain the title compound.

Workup

  1. customwas evaporated under reduced pressure
  2. additionWater was added to the residue
  3. customprecipitates thus
  4. customformed
  5. filtrationwere taken by the filtration
  6. washwashed with water and hexane/ethyl acetate (3/1)
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-46d159fea78e457ab78b3f3c0b1671b8
Source dataset
uspto-grants-2009_02
Patent number
US07494989B2

Reaction notes

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