Acetone → HCID 10117784, compound

HRID 1727905Notes

Reaction equation

HRID 1727905 reaction equation
CC(C)=O.[C:5]1([CH:11]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:12][CH2:13][O:14][C:15]([C:17]2[CH:22]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=3)[C:21]([C:30]([OH:32])=[O:31])=[C:20]([CH3:33])[NH:19][C:18]=2[CH3:34])=[O:16])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[N+]([O-])([O-])=O.[NH4+].[Ce]>O>[C:35]1([CH:11]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:12][CH2:13][O:14][C:15]([C:17]2[C:18]([CH3:34])=[N:19][C:20]([CH3:33])=[C:21]([C:30]([OH:32])=[O:31])[C:22]=2[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=2)=[O:16])[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 9827369HCID 9827369, compoundHCID 57418452Ammonium cerium-nitrate

Product 1

HCID 10117784HCID 10117784, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

2 ml of acetone was added to 50.7 mg (0.100 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid mono (3,3-diphenylpropyl) ester. 130 mg (0.240 mmol) of cerium ammonium nitrate suspended in 1 ml of water was added and stirred at room temperature for 10 minutes. After adding water and extracting with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.

Workup

  1. additionwas added
  2. extractionextracting with ethyl acetate
  3. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-4033948ededf4d12a051f34494313dcd
Source dataset
uspto-grants-2009_02
Patent number
US07494989B2

Reaction notes

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