Potassium Carbonate → HCID 57565903, compound

HRID 1728115Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[F:9].C([O-])([O-])=O.[K+].[K+].Br[CH2:17][CH2:18][O:19][Si:20]([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:17][CH2:18][O:19][Si:20]([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21])=[CH:4][C:3]=1[F:9]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 27791534-Bromo-3-fluorophenol

HCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilane

Product 1

HCID 57565903HCID 57565903, compoundYield 79%

Procedure

In a manner similar to the method described in example 132a, 4-bromo-3-fluoro-phenol (12 g, 62.3 mmol) was reacted with K2CO3 (26 g, 188 mmol) and (2-bromo-ethoxy)-tert-butyl-dimethyl-silane (18.0 g, 75.3 mmol) to give [2-(4-bromo-3-fluoro-phenoxy)-ethoxy]-tert-butyl-dimethyl-silane as yellow oil (17.2 g, 77%).

Sources & evidence

ORD record: ord-d174dfd3aa5f4d9f8f2336454fbab5a0
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07495007B2

Reaction notes

Loading…