Potassium Fluoride → HCID 76567973, compound

HRID 1728156Notes

Reaction equation

HRID 1728156 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]2[NH:8][C:9](=[O:40])[C:10]3([CH:15]([C:16]4[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=4)[CH2:14][C:13](=[O:23])[NH:12][CH:11]3[C:24]3[CH:29]=[C:28]([C:30]#[C:31][Si](C)(C)C)[CH:27]=[CH:26][C:25]=3[S:36]([CH3:39])(=[O:38])=[O:37])[C:5]2=[CH:4][CH:3]=1.[F-].[K+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]2[NH:8][C:9](=[O:40])[C:10]3([CH:15]([C:16]4[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=4)[CH2:14][C:13](=[O:23])[NH:12][CH:11]3[C:24]3[CH:29]=[C:28]([C:30]#[CH:31])[CH:27]=[CH:26][C:25]=3[S:36]([CH3:39])(=[O:38])=[O:37])[C:5]2=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 76568068HCID 76568068, compound

Product 1

HCID 76567973HCID 76567973, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a manner similar to the method described in example 214f, racemic (2′S,3R,4′S)-6-chloro-4′-(3-chlorophenyl)-2′-[2-methylsulfonyl-5-(2-trimethylsilanyl-ethynyl)-phenyl]spiro[3H-indole-3,3′-piperidine]-2,6′-dione reacted with KF in methanol to give the title compound. MS (M+H+) 539

Sources & evidence

ORD record
ord-1e02ea2690204dd8876aa880fdd45871
Source dataset
uspto-grants-2009_02
Patent number
US07495007B2

Reaction notes

Loading…