Pyridine → Phenyl 4-(3-ethynylphenylamino)-7-fluoroquinazolin-6-ylcarbamate

HRID 172820Notes

Reaction equation

HRID 172820 reaction equation
[C:1](#[CH:2])[c:3]1[cH:4][c:5]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([F:21])[c:17]([NH2:20])[cH:18][c:19]23)[cH:6][cH:7][cH:8]1.[Cl:28][C:29](=[O:30])[O:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[O:38]=[CH:39][N:40]([CH3:41])[CH3:42].[cH:22]1[cH:23][cH:24][n:25][cH:26][cH:27]1>>[C:1](#[CH:2])[c:3]1[cH:4][c:5]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([F:21])[c:17]([NH:20][C:29](=[O:30])[O:31][c:32]4[cH:33][cH:34][cH:35][cH:36][cH:37]4)[cH:18][c:19]23)[cH:6][cH:7][cH:8]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6228DimethylformamideHCID 15891Phenyl chloroformateHCID 59142793N4-(3-ethynylphenyl)-7-fluoroquinazoline-4,6-diamine

Product 1

HCID 59142774Phenyl 4-(3-ethynylphenylamino)-7-fluoroquinazolin-6-ylcarbamate

Sources & evidence

ORD record
ord-4be6fe98b80a491ea8b8ea0ff07d5098
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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