HCID 76568150, compound → HCID 76568133, compound

HRID 1728238Notes

Reaction equation

HRID 1728238 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)/[C:10](=[CH:18]/[C:19]2[CH:24]=[C:23]([Br:25])[CH:22]=[CH:21][C:20]=2[O:26][CH2:27][C:28]([F:31])([F:30])[F:29])/[C:9]1=[O:32])=O)(C)(C)C.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][C:35]=1[CH:41]=[N:42][C:43]([O:45][Si](C)(C)C)=[CH2:44]>C1(C)C=CC=CC=1.ClCCl>[F:29][C:28]([F:31])([F:30])[C:27]([OH:45])=[O:26].[Br:25][C:23]1[CH:22]=[CH:21][C:20]([O:26][CH2:27][C:28]([F:29])([F:31])[F:30])=[C:19]([CH:18]2[CH2:44][C:43](=[O:45])[NH:42][CH:41]([C:35]3[CH:36]=[C:37]([Cl:40])[CH:38]=[CH:39][C:34]=3[Cl:33])[C:10]32[C:11]2[C:16](=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[NH:8][C:9]3=[O:32])[CH:24]=1

Participants

6

Reactant 2

HCID 76568150HCID 76568150, compoundHCID 86617605HCID 86617605, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 76568133HCID 76568133, compoundYield 18.5%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 228d, E/Z-3-[5-bromo-2-(2,2,2-trifluoro-ethoxy)-benzylidene]-6-chloro-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (0.53 g, 1 mmol) was reacted with 1-(2,5-dichlorophenyl)-3-trimethylsilyoxy-2-aza-1,3-butadiene prepared in Example 159a (6 mmol) in toluene and then trifluoroacetic acid in dichloromethane to give title compound as a white solid (0.06 g).

Sources & evidence

ORD record
ord-feb9ec61d11d4dd6a3296b6b7e18bfb2
Source dataset
uspto-grants-2009_02
Patent number
US07495007B2

Reaction notes

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