Potassium Carbonate → 2-(4-Chloro-2-formyl-phenoxy)-2-methyl-propionic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	5-Chloro-salicylaldehyde	HCID 12481	—
Reactant	tert-Butyl 2-bromo-2-methylpropionate	HCID 90290	—
Solvent	Dimethylformamide	HCID 6228	—
Product	2-(4-Chloro-2-formyl-phenoxy)-2-methyl-propionic acid tert-butyl ester	HCID 57566221	53.6%

Reaction Conditions

Temperature	110 °C

Reaction Steps

5-Chloro-2-hydroxy-benzaldehyde (15.6 g, 100 mmol), 2-bromo-2-methyl-propionic acid tert-butyl ester (33.4 g, 150 mmol), K2CO3 (27.6 g, 200 mmol) and KI (3 g, 19 mmol) were mixed in DMF (100 mL). Then the reaction mixture was heated at 110° C. for 3 h. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in ethyl acetate and washed with 1N NaOH. Then the organic layer was separated, dried over Na2SO4 and concentrated to give title compound (16 g)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07495007B2
Source dataset	uspto-grants-2009_02
ORD ID	ord-d0ff954518c640ad8406b5d51fc488e2
Source note	uspto-grants-2009_02