反应详情

温度

110 °C

5-Chloro-2-hydroxy-benzaldehyde (15.6 g, 100 mmol), 2-bromo-2-methyl-propionic acid tert-butyl ester (33.4 g, 150 mmol), K2CO3 (27.6 g, 200 mmol) and KI (3 g, 19 mmol) were mixed in DMF (100 mL). Then the reaction mixture was heated at 110° C. for 3 h. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in ethyl acetate and washed with 1N NaOH. Then the organic layer was separated, dried over Na2SO4 and concentrated to give title compound (16 g)

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with 1N NaOH
5. customThen the organic layer was separated
6. dry with materialdried over Na2SO4
7. concentrationconcentrated