Sodium Hydroxide → HCID 19017125, compound

HRID 1728269Notes

Reaction equation

HRID 1728269 reaction equation
[OH:1][CH:2]([CH3:20])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:16]=[CH:15][C:14]([O:17]CC)=[CH:13][N:12]=2)=[CH:7][CH:6]=1.C(OC(C)CCC1C=CC(C2N=CC(OCC)=CN=2)=CC=1)(=O)C.[OH-].[Na+]>C(O)COCCO>[OH:1][CH:2]([CH3:20])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[N:16]=[CH:15][C:14]([OH:17])=[CH:13][N:12]=2)=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 19017192HCID 19017192, compoundHCID 19017245HCID 19017245, compound

Product 1

HCID 19017125HCID 19017125, compoundYield 161.5%

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

2.9 g of (-)-2-[4-(3-hydroxy-1-butyl)phenyl]-5-(ethoxy)pyrimidine, 3.1 g of (-)-2-[4-(3-acetoxy-1-butyl)phenyl]-5-(ethoxy)pyrimidine, 8 g of sodium hydroxide and 60 ml of diethylene glycol were reacted in an analogous manner to Example 1(c) to give 4.2 g of (-)-2-[4-(3-hydroxy-1-butyl)phenyl]-5-hydroxypyrimidine.

Sources & evidence

ORD record
ord-d7fd9cbc556d43f09a62ed886421d6fb
Source dataset
uspto-grants-1994_07
Patent number
US05326497

Reaction notes

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