HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphate → (-)-2-[4-(3-Hydroxy-1-butyl)-phenyl]-5-hydroxy-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphate | HCID 1061 | — |
| Reactant | 2-[4-(3-Acetoxy-1-butyl)phenyl]-5-trimethylsilyloxy-pyridine | HCID 19017251 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (-)-2-[4-(3-Hydroxy-1-butyl)-phenyl]-5-hydroxy-pyridine | HCID 19017166 | — |
| Product | (-)-2-[4-(3-Acetoxy-1-butyl)phenyl]-2-hydroxy-pyridine | HCID 67824305 | — |
Reaction Steps
12 g of 2-[4-(3-acetoxy-1-butyl)phenyl]-5-trimethylsilyloxy-pyridine, 300 ml of 0.3M phosphate buffer solution (pH 7.0), 30 ml of chloroform and 3.0 g of lipase (genus Arthobacter) are reacted to give 4.5 g of (-)-2-[4-(3-hydroxy-1-butyl)-phenyl]-5-hydroxy-pyridine and 4.2 g of (-)-2-[4-(3-acetoxy-1-butyl)phenyl]-2-hydroxy-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05326497 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-0c33416f645e4e9eb7ff733f7d23ab2c |
| Source note | uspto-grants-1994_07 |