Hydrochloric Acid → HCID 19017554, 화합물

HRID 1728316노트

반응식

HRID 1728316 반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([F:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[F:13][C:14]([F:32])([F:31])[C:15]1[CH:16]=[CH:17][C:18]([O:21][C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][OH:30])=[CH:24][CH:23]=2)=[N:19][CH:20]=1.Cl>C1(C)C=CC=CC=1>[F:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[CH:4][N:3]=[C:2]2[O:30][CH2:29][CH2:28][C:25]1[CH:24]=[CH:23][C:22]([O:21][C:18]2[CH:17]=[CH:16][C:15]([C:14]([F:32])([F:13])[F:31])=[CH:20][N:19]=2)=[CH:27][CH:26]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 19017550HCID 19017550, 화합물HCID 199391334-Chloro-8-fluoroquinazoline

생성물 1

HCID 19017554HCID 19017554, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 4-chloro-8-fluoroquinazoline (2.12 g, 12 mmol) and 2-(4-(5-(trifluoromethyl)-2-pyridinyloxy)phenyl)ethanol (2.83 g, 10 mmol) in 50 mL of toluene containing a catalytic amount of hydrogen chloride was stirred for several days. The title product was isolated by column chromatography. Yield 1.6 g. MP 116°-118° C.

출처 및 근거

ORD 기록
ord-5efa02973c614b169a2ac2caae5e2a90
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05326766

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