Tetrahydrofuran → 2-(4-benzyl-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)acetonitrile

HRID 172832Notes

Reaction equation

HRID 172832 reaction equation
[Br:1][CH2:2][C:3]#[N:4].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH2:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[c:12]1[c:13]2[c:14]([n:15][c:16]([NH:18][c:19]3[cH:20][c:21]([O:31][CH3:32])[c:22](-[n:25]4[cH:26][n:27][c:28]([CH3:30])[cH:29]4)[cH:23][cH:24]3)[n:17]1)[CH2:33][CH2:34][NH:35][CH2:36]2>>[CH2:2]([C:3]#[N:4])[N:35]1[CH2:34][CH2:33][c:14]2[c:13]([c:12]([CH2:5][c:6]3[cH:7][cH:8][cH:9][cH:10][cH:11]3)[n:17][c:16]([NH:18][c:19]3[cH:20][c:21]([O:31][CH3:32])[c:22](-[n:25]4[cH:26][n:27][c:28]([CH3:30])[cH:29]4)[cH:23][cH:24]3)[n:15]2)[CH2:36]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 11534BromoacetonitrileHCID 593336984-Benzyl-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine

Product 1

HCID 593337672-(4-benzyl-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)acetonitrile

Sources & evidence

ORD record
ord-b4fc675c44ee486faeee80f804bbd303
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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