Hydroxylamine → HCID 19017744, compound

HRID 1728344Notes

Reaction equation

HRID 1728344 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[CH:4][C:3]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].[C:12]1(S(OCCC)(=O)=O)[CH:17]=CC=C[CH:13]=1.[NH2:25]O>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:25][CH2:13][CH2:12][CH3:17])[C:3]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

4

Reactant 3

HCID 787HydroxylamineHCID 220447Benzenesulfonic acid, propyl esterHCID 7009317Ethyl 5-methylisoxazole-4-carboxylate

Product 1

HCID 19017744HCID 19017744, compound

Procedure

Ethyl 5-methylisoxazole-4-carboxylate is quaternized with propyl benzenesulfonate and the resulting quaternary salt is reacted with hydroxylamine to give the title compound according to the procedure of A. Alberola et al., Synthesis 203 (1988).

Sources & evidence

ORD record
ord-2d9b4c7d4fd34675adf80b48cf590927
Source dataset
uspto-grants-1994_07
Patent number
US05326776

Reaction notes

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