Hydrochloric Acid → HCID 21754075, compound

Participants

Reaction Steps

1.0 g of 1-(8-chloro-5-quinolinesulfonylaminoethyl)-4-[3-(phenylthio)propyl]piperazine obtained in Example 1 was dissolved in 10 ml of methanol, and to the resultant solution was added a 2-equivalent amount of an aqueous hydrochloric acid, followed by stirring for 10 minutes. Then, solvent removal was conducted by distillation under reduced pressure to obtain a residue. The thus obtained residue was subjected to recrystallization using a mixture of ethanol and ether to obtain 0.84 g of 1-(8-chloro-5-quinolinesulfonylaminoethyl)-4-[3-(phenylthio)propyl]piperazine dihydrochloride (yield: 73%).

Provenance & Evidence