Hydrochloric Acid → HCID 21754075, compound

HRID 1728398Notes

Reaction equation

HRID 1728398 reaction equation
[Cl:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([S:12]([NH:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][S:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:20][CH2:19]2)(=[O:14])=[O:13])=[CH:4][CH:3]=1.[ClH:34]>CO>[ClH:1].[ClH:34].[Cl:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([S:12]([NH:15][CH2:16][CH2:17][N:18]2[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][S:27][C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH2:22][CH2:23]2)(=[O:13])=[O:14])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21754064HCID 21754064, compound

Product 1

HCID 21754075HCID 21754075, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.0 g of 1-(8-chloro-5-quinolinesulfonylaminoethyl)-4-[3-(phenylthio)propyl]piperazine obtained in Example 1 was dissolved in 10 ml of methanol, and to the resultant solution was added a 2-equivalent amount of an aqueous hydrochloric acid, followed by stirring for 10 minutes. Then, solvent removal was conducted by distillation under reduced pressure to obtain a residue. The thus obtained residue was subjected to recrystallization using a mixture of ethanol and ether to obtain 0.84 g of 1-(8-chloro-5-quinolinesulfonylaminoethyl)-4-[3-(phenylthio)propyl]piperazine dihydrochloride (yield: 73%).

Workup

  1. customThen, solvent removal
  2. distillationwas conducted by distillation under reduced pressure
  3. customto obtain a residue
  4. customThe thus obtained residue was subjected to recrystallization
  5. additiona mixture of ethanol and ether

Sources & evidence

ORD record
ord-4d5e2f05a1a443ddb6ce66e3615d04eb
Source dataset
uspto-grants-1994_07
Patent number
US05326870

Reaction notes

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