HCID 23364465, compound → HCID 9796098, compound

HRID 1728402Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[N:11]=[CH:12][C:13]2[NH:22][C:21]3[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=3[C:14]=2[N:15]=1>[Pd]>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[N:11]=[CH:12][C:13]2[NH:22][C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:14]=2[N:15]=1

Participants

Conditions

Temperature: 230 °C

Procedure

A mixture of 2-(2-fluoro-4-methoxyphenyl)-6,7,8,9-tetrahydro-5H-indolo[3,2-d]pyrimidine (300 mg) and palladium black (300 mg) in 3 mL of mesityline was stirred at 230° C. in a sealed tube for 1 h. The reaction mixture was filtered and the residue subjected to flash chromatography on silica gel with 30% ethyl acetate/hexane as the eluent. In this manner 2-(2-Fluoro-4-methoxyphenyl)-5H-indolo[3,2-d]pyrimidine (Compound 1), m.p. 202°-203° C. was obtained as white crystals.

Workup

filtrationThe reaction mixture was filtered

Sources & evidence

ORD record: ord-ec309b90eb33478c872d1846c773a2a7
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05326868

Reaction notes

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