Diethyl biphenyl-4-ylmethylphosphonate → HCID 19967088, compound

HRID 1728453Notes

Reaction equation

HRID 1728453 reaction equation
[C:1]1([C:7]2[CH:21]=[CH:20][C:10]([CH2:11][P:12](=[O:19])([O:16]CC)[O:13]CC)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>Cl>[C:1]1([C:7]2[CH:21]=[CH:20][C:10]([CH2:11][P:12](=[O:13])([OH:19])[OH:16])=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 520494Diethyl biphenyl-4-ylmethylphosphonate

Product 1

HCID 19967088HCID 19967088, compoundYield 16.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A vigorously stirred suspension of 3.5 g (12 mmol) of diethyl 4-phenylbenzylphosphonate in 35 ml of concentrated hydrochloric acid was refluxed for 45 hours and cooled to room temperature. The solids were filtered, washed with water and then recrystallized from EtOH to give 0.5 g of product; m.p. 246°-248° C.

Workup

  1. temperaturewas refluxed for 45 hours
  2. filtrationThe solids were filtered
  3. washwashed with water
  4. customrecrystallized from EtOH

Sources & evidence

ORD record
ord-4d8bc3215e8f48daab2f00076d638025
Source dataset
uspto-grants-1994_07
Patent number
US05326905

Reaction notes

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