Urea → N-Hydroxy-N-[4-[1-ethoxy-3-(3,4-dimethoxyphenyl)prop-2-yn-1-yl]benzyl]urea

HRID 1728456Notes

Reaction equation

HRID 1728456 reaction equation
[OH:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([O:23][CH2:24][CH3:25])[C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=2)=[CH:6][CH:5]=1.COC1C=C(C#C)C=CC=1OC.[NH2:38][C:39](N)=[O:40]>>[OH:1][N:2]([CH2:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([O:23][CH2:24][CH3:25])[C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=2)=[CH:8][CH:9]=1)[C:39]([NH2:38])=[O:40]

Participants

4

Reactant 3

HCID 1176UreaHCID 36164214-Ethynyl-1,2-dimethoxybenzeneHCID 190181881-[4-Hydroxyaminomethylphenyl]-3-[3,4-dimethoxyphenyl]1-ethoxy-prop-2-yne

Product 1

HCID 19018194N-Hydroxy-N-[4-[1-ethoxy-3-(3,4-dimethoxyphenyl)prop-2-yn-1-yl]benzyl]urea

Procedure

1-[4-hydroxyaminomethylphenyl]-3-[3,4-dimethoxyphenyl]1-ethoxy-prop-2-yne, prepared from 3,4-dimethoxyphenylacetylene according to Example 5, was converted into the corresponding urea compound following the procedure of Example 8.

Sources & evidence

ORD record
ord-b9c26cace278433d9d45a9907ea96188
Source dataset
uspto-grants-1994_07
Patent number
US05326902

Reaction notes

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