Hydrochloric Acid → HCID 178501353, compound

HRID 1728478Notes

Reaction equation

HRID 1728478 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[N:8]([C:9](=[O:11])[CH3:10])[C:7](=[O:12])[C@H:6]1[CH2:13][CH2:14][CH2:15][NH:16][C:17]([NH:29]C(OCC1C=CC=CC=1)=O)=[N:18]C(OCC1C=CC=CC=1)=O)=[O:4].[ClH:40]>[Pd].CO.C(OCC)(=O)C>[ClH:40].[CH3:1][O:2][C:3]([C@@H:5]1[N:8]([C:9](=[O:11])[CH3:10])[C:7](=[O:12])[C@H:6]1[CH2:13][CH2:14][CH2:15][NH:16][C:17]([NH2:29])=[NH:18])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178501350HCID 178501350, compound

Product 1

HCID 178501353HCID 178501353, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

A methanol/ethyl acetate (2.5 mL/2.5mL) solution of compound 9 (313 mg, 0.58 mmol) and 1N HCl (0.58 mL) was stirred under a hydrogen atmosphere with 10% palladium on carbon catalyst. When the starting material had disappeared as determined by TLC, the reaction mixture was passed through a pad of Celite and the filtrate was concentrated to afford 150 mg (84%) of the title product as a yellow foam.

Workup

  1. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-9c1dbd6badbe4a759376d86d37d4b532
Source dataset
uspto-grants-1994_07
Patent number
US05326863

Reaction notes

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