Hydrochloric Acid → HCID 178501354, compound

HRID 1728480Notes

Reaction equation

HRID 1728480 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[N:8]([S:9]([CH3:12])(=[O:11])=[O:10])[C:7](=[O:13])[C@H:6]1[CH2:14][CH2:15][CH2:16][NH:17][C:18]([NH:30]C(OCC1C=CC=CC=1)=O)=[N:19]C(OCC1C=CC=CC=1)=O)=[O:4].[ClH:41].[H][H]>[Pd].CO>[ClH:41].[CH3:1][O:2][C:3]([C@@H:5]1[N:8]([S:9]([CH3:12])(=[O:11])=[O:10])[C:7](=[O:13])[C@H:6]1[CH2:14][CH2:15][CH2:16][NH:17][C:18]([NH2:30])=[NH:19])=[O:4]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 178418361HCID 178418361, compoundHCID 178501351HCID 178501351, compound

Product 1

HCID 178501354HCID 178501354, compoundYield 30%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A methanol solution of compound 11 (0.29 g, 0.5 mmol) and 1N HCl (0.5 mL), containing 10% palladium on carbon, was stirred under 35 psi of hydrogen atmosphere for 2 h. The suspension was filtered through a pad of Celite and the filtrate was concentrated to afford 52 mg (30%) of the title product.

Workup

  1. filtrationThe suspension was filtered through a pad of Celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-4b02d02611444a64908917ea04de4e57
Source dataset
uspto-grants-1994_07
Patent number
US05326863

Reaction notes

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