Hydrochloric Acid → HCID 178477455, compound

HRID 1728484Notes

Reaction equation

HRID 1728484 reaction equation
[CH2:1]([S:3][C@@H:4]1[N:7]([C:8](=[O:10])[CH3:9])[C:6](=[O:11])[C@H:5]1[CH2:12][CH2:13][CH2:14][NH:15][C:16]([NH:28]C(OCC1C=CC=CC=1)=O)=[N:17]C(OCC1C=CC=CC=1)=O)[CH3:2].[ClH:39]>[Pd].CO.C(OCC)(=O)C>[ClH:39].[CH2:1]([S:3][C@@H:4]1[N:7]([C:8](=[O:10])[CH3:9])[C:6](=[O:11])[C@H:5]1[CH2:12][CH2:13][CH2:14][NH:15][C:16]([NH2:28])=[NH:17])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178477454HCID 178477454, compound

Product 1

HCID 178477455HCID 178477455, compoundYield 68%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

A methanol/ethyl acetate (1.5 mL/1.5 mL) solution of compound 18 (117 mg, 0.19 mmol) and 1N HCl (0.19 mL), containing 10% palladium on carbon, was stirred under a hydrogen atmosphere until TLC indicated the disappearance of the starting material (about 1 h). The suspension was filtered through a pad of Celite, and the filtrate was concentrated to afford 40 mg (68%) of the title product as a foam.

Workup

  1. customthe disappearance of the starting material (about 1 h)
  2. filtrationThe suspension was filtered through a pad of Celite
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-40116e76769a47af81c496a9983073bb
Source dataset
uspto-grants-1994_07
Patent number
US05326863

Reaction notes

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