Hydrochloric Acid → HCID 178473807, compound

HRID 1728485Notes

Reaction equation

HRID 1728485 reaction equation
C([N:11]=[C:12]([NH:25]C(OCC1C=CC=CC=1)=O)[NH:13][CH2:14][CH2:15][CH2:16][CH:17]1[CH2:20][N:19]([C:21](=[O:23])[CH3:22])[C:18]1=[O:24])(OCC1C=CC=CC=1)=O.[ClH:36]>[Pd].CO.C(OCC)(=O)C>[ClH:36].[NH:13]([CH2:14][CH2:15][CH2:16][CH:17]1[CH2:20][N:19]([C:21](=[O:23])[CH3:22])[C:18]1=[O:24])[C:12]([NH2:25])=[NH:11]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178473806HCID 178473806, compound

Product 1

HCID 178473807HCID 178473807, compoundYield 69%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

A methanol/ethyl acetate (2.5 mL/2.5 mL) solution of compound 20 (255 mg, 0.58 mmol) and 1N HCl (0.58 mL), containing 10% palladium on carbon, was stirred under a hydrogen atmosphere until TLC indicated the disappearance of the starting material (about 10 min). The suspension was filtered through a pad of Celite, and the filtrate was concentrated to afford 99 mg (69%) of the title compound as a yellow foam.

Workup

  1. customthe disappearance of the starting material (about 10 min)
  2. filtrationThe suspension was filtered through a pad of Celite
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-7728f8fb70394fa3ac7cff2fb912eb63
Source dataset
uspto-grants-1994_07
Patent number
US05326863

Reaction notes

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