Dichloromethane → 4-Fluoro-4-(methylsulfonyloxymethyl)-1-piperidinecarboxylic acid tert-butyl ester

HRID 172849Notes

Reaction equation

HRID 172849 reaction equation
[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[CH3:24][S:25]([Cl:26])(=[O:27])=[O:28].[Cl:29][CH2:30][Cl:31].[F:1][C:2]1([CH2:15][OH:16])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[F:1][C:2]1([CH2:15][O:16][S:25]([CH3:24])(=[O:27])=[O:28])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 22248400tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 222484024-Fluoro-4-(methylsulfonyloxymethyl)-1-piperidinecarboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-88d5547bb9c34a59998764c2c5107c26
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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