反应详情

Into a 100 ml-round bottomed flask, 1.52 g (11 mW) of p-hydroxybenzoic acid in 20 ml of ethanol was added. Thereto, 1.45 g (26 mM) of potassium hydroxide in 5 ml of water was added, and 2.15 g (10 mM) of 2-fluorooctyl bromide in 2 ml of ethanol was added, followed by 25 hours of heat refluxing. Thereafter, a solution of 1.45 g (26 mM) of potassium hydroxide in 3 ml of water was added, followed by 5 hours of heat refluxing. After the completion of the reaction, the system was cooled with ice and neutralized with conc. HCl to precipitate a crystal. The crystal was filtered out, and washed with 50 ml of water to recover 1.00 g (yield: 37%) of p-2-fluorooctyloxybenzoic acid.

1. temperatureof heat
2. temperaturerefluxing
3. waitfollowed by 5 hours
4. temperatureof heat
5. temperaturerefluxing
6. customAfter the completion of the reaction
7. customto precipitate a crystal
8. filtrationThe crystal was filtered out
9. washwashed with 50 ml of water